Journal of Basic and Applied Research in Biomedicine 2020-09-07T20:32:25+00:00 Haitham Qaralleh Open Journal Systems <p>****************************************************************</p> <p>This site is under construction, all info about the journal is available <a href="" target="_blank" rel="noopener">here</a></p> <p><strong>***Submit your manuscript to:***</strong></p> <p>*****************************************************************</p> <p>The “Journal of basic and applied research in biomedicine” was first published in 2015 as “Journal of basic and applied research”. Since 2019, the title of the journal was changed to “Journal of basic and applied research in biomedicine”. It is independent, international, double blind peer reviewed journal with a broad scope that cover all aspects related to biomedical sciences and human health. Two volumes are published every year and the manuscript is published in electronic formats as soon as it accepted. The journal is licensed under a Creative Commons Attribution 4.0 International License and all published articles are freely available.</p> <p>Aims and Scope</p> <p>Journal of basic and applied research in biomedicine cover all aspects related to biomedical sciences and human health. This includes all fundamental and molecular aspects of medical sciences and clinical investigation. Original researches reporting innovative idea for conquering human health problems are given high priority. It covers various fields of biomedicine include (but not limited to): microbiology, biochemistry, immunology, physiology, neurology, toxicology, oncology, pharmacology and medicinal chemistry. Also, environmental research reporting significant impact on human health is considered.</p> Biodegradation of Phenol: Mini Review 2020-08-22T19:45:13+00:00 Razan Saraireh Batool Asasfeh Mutaz Saraireh Kholoud Shiyyab Rawan Shawawreh <p>This paper is a comprehensive review related to the biological degradation of phenol by microorganisms. The aromatic compound, phenol or hydroxybenzene, is produced industrially or naturally. Many microorganisms that are able to biodegrade phenol have been isolated and at the same time, the metabolic pathways responsible for these metabolic processes have been determined. A large number of bacteria were studied in detail especially, pure cultures as well as the pathways of aerobic phenol metabolism and the enzymes involved. Phenol oxygenation occurred as the initial steps through phenol hydroxylase enzymes leading to formation of catechol, pursued by the splitting of the adjacent ring or in between the two groups of catechol hydroxyls. Thus, the physical and chemical environments plus the chemical structures that affecting biodegradation processes are important determining factors for combating of pollution. This nature of chemical structure for the other aromatic compounds is also a main decisive factor of biodegradability.</p> 2020-09-03T00:00:00+00:00 Copyright (c) 2020 Journal of Basic and Applied Research in Biomedicine Bioactive Natural Medicinal Plants in South Indian Western Ghats and Their Pharmacological Importance 2020-08-22T19:58:04+00:00 M. Tamizharasi R. Rajila D. Beula Shiny J. Vijila Jasmin T. Kumaran <p>Awareness of traditional knowledge and medicinal plants can play a key role in the utilization and discovery of natural plant resources. Plants became the basis of medicine system throughout the world for thousands of years and continue to provide mankind with new remedies.&nbsp;Researchers generally agree that natural products from plants and other organisms have been the most consistently successful source for ideas for new drugs. The world health organization estimates that 80% of the population living in the developing countries relies exclusively on traditional medicine for their primary health care. More than half of the world's population still relies entirely on plants for medicines, and plants supply the active ingredients of most traditional medical products. The review shows the south Indian medicinal plant products has been used by people to treat various health ailments.</p> 2020-09-03T00:00:00+00:00 Copyright (c) 2020 Authors Structure and Process Evaluation of Cold Chain Management and Routine Immunization Services in Rural Western Gujarat 2020-08-31T20:17:54+00:00 Pithadia Pradeep R Shah Viral R Makwana Naresh R Parmar Dipesh <p>Maintenance of cold chain points are vital for preserving potency of vaccines for immunization of children and thereby averting vaccine preventable diseases in the community. Cold chain handlers should have sufficient knowledge and skills related to cold chain equipment handling and immunization practices.&nbsp; The present study aims to evaluate maintenance of cold chain facilities at primary health care centers (PHCs), related logistics and observation of Mamta Day (Immunization Day). The observations include knowledge and practice of health workers about immunization activities, their communication skills, training status etc. Methods: There are total 31 Primary Health Centers in Jamnagar district, out of which, we decided to include 50% (15) of primary health centers and observed their cold chain, and Immunization day at a subcentre or Anganwadi centre of the selected PHC to assess the quality of immunization services. We included equal number of cold chain points from each block of the district to make it representative of entire district. <strong>Results: </strong>&nbsp;Average population served by a cold chain point is 21985. Vaccine related logistics like cold boxes, vaccine carriers etc. were adequate in all facilities. All cold chain equipments were placed as per standard guidelines. The posts of medical officers and pharmacists were vacant in almost one fourth of cold chain points and they were run on deputation from other facilities. The knowledge and skills of health workers related to immunization practices were found to be satisfactory. Conclusion: &nbsp;We observed that routine immunization program was implementing in the district satisfactorily. The posts of medical officers and pharmacists need to be filled up at the earliest for smooth functioning of immunization program in primary health centres.</p> 2020-09-03T00:00:00+00:00 Copyright (c) 2020 Authors Retrospective Study of Biochemical Markers and Risk Factors in Obese and Non-Obese Adolescence 2020-08-29T03:47:33+00:00 D. Jayarajan V. Abirami <p>Obesity is a chronic disease defined by an excessive accumulation of body fat that represents health risks, being considered now a days the major public health problem worldwide. Obesity is characterized as a low-grade inflammatory disease due to the variety of pro-inflammatory adipokines secreted by adipose tissue, especially visceral adipose tissue. This inflammation is characterized by macrophage infiltration and expression of inflammatory adipokines, which are related to insulin resistance, blood pressure, and vascular endothelium alterations. These alterations are closely related to development and progression of diabetes and cardiovascular disease, including paediatric patients. Obesity considered now as&nbsp; one among &nbsp;the major global issue affecting young adults. Rapid changes in sedentary lifestyle choices were the risk factors for obesity including unhealthy diet patterns, expending time in front of TV &nbsp;and lacking physical activity etc. The present study aimed for correlating the risk factors of obesity with healthy groups among the adolescent population. And the result were recorded with significant level of elevation in most of the parameters &nbsp;in cases than control and the significance was represented as student’s test. (p&lt;0.001).</p> 2020-09-08T00:00:00+00:00 Copyright (c) 2020 D. Jayarajan devadass pakkiam, V. Abirami COVID-19: An Emerging Rapidly Evolving Situation 2020-09-07T20:32:25+00:00 Bhairav Prasad Neha Prasad <p>Coronaviruses are large group of enveloped viruses with unsegmented, single-stranded, positive-sense RNA as genetic material. These are collection related&nbsp;RNA viruses&nbsp;that cause diseases of economically important vertebrate viz.&nbsp;mammals&nbsp;and&nbsp;birds. In humans, these&nbsp;viruses&nbsp;cause&nbsp;respiratory tract infections&nbsp;that can range from asymptomatic to life threatening. The asymptomatic disease include very similar to some cases of the&nbsp;common cold, while other deadly varieties can cause&nbsp;SARS,&nbsp;MERS, and&nbsp;COVID-19. The SARS-CoV (severe acute respiratory syndrome coronavirus) and MERS-CoV (Middle East respiratory syndrome coronavirus) are zoonotic origin and extremely pathogenic coronaviruses that can cause localized and worldwide outbreak. The novel Coronaviruses, COVID-19 posses a unique morphology. &nbsp;The outer surface of the virus bearing surface spike and reveled like crown hence being named corona virus. The mode of replication of the virus is very unique as it replicate through the generation of nested set of viral mRNA. The HCoV (Human coronavirus) cause respiratory complication with asymptomatic to life threatening outcomes. From the past 15 years we have witnessed appearance of two zoonotic, extremely pathogenic human corona viruses the: &nbsp;SARS-CoV and MERS-CoV.</p> 2020-09-23T00:00:00+00:00 Copyright (c) 2020 Bhairav Prasad, Neha Prasad