Retrospective Study of Biochemical Markers and Risk Factors in Obese and Non-Obese Adolescence

Main Article Content

D. Jayarajan
V. Abirami


Obesity is a chronic disease defined by an excessive accumulation of body fat that represents health risks, being considered now a days the major public health problem worldwide. Obesity is characterized as a low-grade inflammatory disease due to the variety of pro-inflammatory adipokines secreted by adipose tissue, especially visceral adipose tissue. This inflammation is characterized by macrophage infiltration and expression of inflammatory adipokines, which are related to insulin resistance, blood pressure, and vascular endothelium alterations. These alterations are closely related to development and progression of diabetes and cardiovascular disease, including paediatric patients. Obesity considered now as  one among  the major global issue affecting young adults. Rapid changes in sedentary lifestyle choices were the risk factors for obesity including unhealthy diet patterns, expending time in front of TV  and lacking physical activity etc. The present study aimed for correlating the risk factors of obesity with healthy groups among the adolescent population. And the result were recorded with significant level of elevation in most of the parameters  in cases than control and the significance was represented as student’s test. (p<0.001).


Download data is not yet available.

Article Details

How to Cite
Jayarajan, D. ., & Abirami, V. (2020). Retrospective Study of Biochemical Markers and Risk Factors in Obese and Non-Obese Adolescence . Journal of Basic and Applied Research in Biomedicine, 6(2), 75-81. Retrieved from


Baingana, F.K., Bos, E.R.(Eds). (2006) Changing Patterns of Disease and Mortality in Sub-Saharan Africa: An Overview. In: Jamison DT, 2nd ed. Washington (DC): World Bank; 2006. Available from:

Blomster, J.I., Zoungas, S., Chalmers, J., Li, Q., Chow, C.K, Woodward, M, et al. (2014).The Relationship Between Alcohol Consumption and Vascular Complications and Mortality in Individuals With Type 2 Diabetes. Diabetes Care. 37(5):1353–9.

Bundred, P. (2001).Prevalence of overweight and obese children between 1989 and 1998: population based series of cross sectional studies. BMJ. 322(7282):326–326.

Capodaglio, P., Liuzzi, A. (2013). Obesity: a disabling disease or a condition favoring disability? Eur J Phys Rehabil Med, 49(3): 395–398

Cefalu, W.T., Bray, G.A., Home, P.D., Garvey, W.T., Klein, S., Pi-Sunyer, F.X, et al(2015). Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors’ Expert Forum. Diabetes Care. 38(8):1567–82

Chan, R.S., Woo, J. (2010).Prevention of Overweight and Obesity: How Effective is the Current Public Health Approach. Int J Environ Res Public Health. 7(3):765–83.

Chapman, I.M. (Eds).(2010). Obesity Paradox during Aging. In: Mobbs CV, Hof PR, editors. Interdisciplinary Topics in Gerontology. Basel: KARGER; 20–36. Available from:

DeBoer, M.D. (2013).Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: A need for screening tools to target interventions. Nutrition. 29(2):379–86.

Flegal, K.M., Carrol, M.D., Ogden, C.L., Johnson, C.L.(2002). Prevalence and trends in obesity among US adults, 1999-2000 [Internet]. JAMA. 2002 [cited 2020 Aug 17]. Available from:

Franczyk-Skóra, B., Gluba, A., Banach, M., Rysz, J.(2013). Treatment of non-ST-elevation myocardial infarction and ST-elevation myocardial infarction in patients with chronic kidney disease. Arch Med Sci AMS. 30;9(6):1019–27.

Ghosh, A.(2007). Factor analysis of risk variables associated with metabolic syndrome in Asian Indian adolescents. Am J Hum Biol. ;19(1):34–40.

Gordon-Larsen, P., Adair, L.S, Suchindran, C.M. (2007).Maternal Obesity Is Associated With Younger Age at Obesity Onset in U.S. Adolescent Offspring Followed Into Adulthood. Obesity. 1;15(11):2790–6.

Gouda, J., Prusty, R.K. (2014). Overweight and Obesity among Women by Economic Stratum in Urban India. J Health Popul Nutr. 32(1):79–88

Güngör, N.K.(2014). Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol. 6(3):129–43

Kasuga, M.(2006).Insulin resistance and pancreatic ? cell failure. J Clin Invest. 3;116(7):1756–60.

Kaur, M., Singh, A., Bassi, R., Kaur, H. (2015). Nutritional status and anemia in medical students of SGRDIMSAR Amritsar. Natl J Physiol Pharm Pharmacol. 5(1):45–9.

Khurana, R., Ranches, G., Schafferer, S., Lukasser, M., Rudnicki, M., Mayer, G. et al. (2017). Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease. RNA. 23(2):142–52.

Koyuncuo?lu Güngör, K. (2014). “Overweight and Obesity in Children and Adolescents,” Jcrpe, 129–143, doi: 10.4274/jcrpe.1471.

Lee, C.M.Y., Huxley, R.R., Wildman, R.P., Woodward, M.(2008). Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. J Clin Epidemiol. 61(7):646–53

Li, S-S., Pan, S., Ma, Y-T., Yang, Y-N., Ma, X., Li, X-M., et al. (2014).Optimal cutoff of the waist-to-hip ratio for detecting cardiovascular risk factors among Han adults in Xinjiang. BMC Cardiovasc Disord. 14(1):1–8.

Lopez, A.D., Mathers, C.D., Ezzati, M., Jamison, D.T., Murray, C.J, (Eds). (2006) Global Burden of Disease and Risk Factors [Internet]. Washington (DC): World Bank; 2006. Available from:

Lopez, J., Carl, A., Burtis, & David, E.(2015).Bruns: Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th ed. Indian J Clin Biochem. ;30(2):243.

Manolopoulos, K.N., Karpe, F,, Frayn, K.N. (2010). Gluteofemoral body fat as a determinant of metabolic health. Int J Obes. 34(6):949–59

Menzie, C.M., Yanoff, L.B., Denkinger, B.I., McHugh, T., Sebring, N.G., Calis, K.A, et al.(2008). Obesity-Related Hypoferremia Is Not Explained by Differences in Reported Intake of Heme and Nonheme Iron or Intake of Dietary Factors that Can Affect Iron Absorption. J Am Diet Assoc. 108(1):145–8.

Patil, L.G.C., Srinivas, S. (2018).Comparison of clinical and biochemical profile of obese and nonobese children. Int J Contemp Pediatr.24;6(1):185.

Pi-Sunyer, F.X. (2004). The epidemiology of central fat distribution in relation to disease [Internet]. Nutrition Reviews, (62)120–126,

Ramachandran, A., Snehalatha, C., Vinitha, R., Thayyil, M., Sathish Kumar, C.K., Sheeba, L, et al. (2002). Prevalence of overweight in urban Indian adolescent school children. Diabetes Res Clin Pract. 57(3):185–90.

Rao, S.N., Gurumurthy, G.P., Gururajan, P., Arumugam, S.B., Saibabu Kirthivasan, V, et al.(2010). Clinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents. Indian J Pediatr. 77(5):555–9

Reilly, J.J. (2006). Obesity in childhood and adolescence: evidence based clinical and public health perspectives. Postgrad Med J. 1;82(969):429–37.

Seidell, J.C.(1995). The impact of obesity on health status: some implications for health care costs,” Int. J. Obes. Relat. Metab. Disord., 19 ( 6)13-16.

Sharma, N., Gupta, R.A.(2016). study of yoga in anemic patients. Int J Med Sci Public Health. 5(3):399.

Sturm, R.(2002). The Effects Of Obesity, Smoking, And Drinking On Medical Problems And Costs. Health Aff (Millwood). Mar;21(2):245–53

Sundquist, J., Johansson, S.E. (1998).The influence of socioeconomic status, ethnicity and lifestyle on body mass index in a longitudinal study. Int J Epidemiol. 1;27(1):57–63.

Valente, T.W., Fujimoto, K., Chou, C.P., Spruijt Metz, D.(2009). Adolescent Affiliations and Adiposity: A Social Network Analysis of Friendships and Obesity. J Adolesc Health Off Publ Soc Adolesc Med. 45(2):202–4.

Williams, D.P., Going, S.B., Lohman, T.G., Harsha, D.W., Srinivasan, S.R., Webber, L.S, et al. (1992). Body fatness and risk for elevated blood pressure, total cholesterol, and serum lipoprotein ratios in children and adolescents. Am J Public Health. 82(3):358–63.

Yanoff, L., Menzie, C., Denkinger, B., Sebring, N., McHugh, T., Remaley, A., et al.(2007). Inflammation and iron deficiency in the hypoferremia of obesity. Int J Obes 2005. 31(9):1412–9.

Ying, X., Song, Z., Zhao, C., Jiang, Y.(2010). Body mass index, waist circumference, and cardiometabolic risk factors in young and middle-aged Chinese women. J Zhejiang Univ Sci B. 11(9):639–46.

Zimmermann, M.B., Zeder, C., Muthayya, S., Winichagoon, P., Chaouki, N., Aeberli, I, et al. (2008).Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes. 32(7):1098–104.