Study of Lipid Profile in Diabetes Mellitus with and without Hypertension

Main Article Content

Jay Jha
Varun Malhotra
Om Jha
Shivani Gupta


Introduction Alterations in the lipid metabolism have been reported in the subject of diabetes mellitus. They may be influenced by the presence of hypertension. Aims The present study was undertaken to estimate the serum lipids profiles of diabetics with and without hypertension. Study design The study design is experimental with comparative study method, Methodology The sample size taken is 80 which is divided into four groups as A group of 20 healthy individuals of age 20-70 years, other B group of 20 diabetic patients without Hypertension, other C group of 20 hypertensive patients without diabetes and the rest 20 diabetic patients along with hypertension of age 20-70 years of D group. They were matched with respect to various lipid parameters such as
total cholesterol, Triglycerides, ?: ? lipoprotein ratio etc. with control group A. Place and duration of study: the study took place at Santosh group of institutions between August 2013 to August 2016. Result The serum cholesterol levels were significantly higher in hypertensives without diabetics and in diabetics with hypertension as compared to normal controls. No significant difference in the serum triglyceride level was observed among various groups in this study. The ?: ? lipoprotein ratio was found to be affected in all the groups as compared to controls with maximum ratio in diabetics without hypertension and in hypertension without diabetes. Patients who were suffering from diabetes and hypertension were at a maximum risk of developing atherosclerosis
and its complications such as coronary artery disease. Diabetics with hypertension had significant higher levels of cholesterol as compared to that of without hypertension. The diabetics with hypertension had lipid abnormalities because of diabetic element in them rather than the hypertension. All the groups studied except the controls were found to be increasingly susceptible to the risk of atherosclerosis and its complications. This risk was found to be maximum in diabetics with hypertension rather than diabetics or hypertensive’s alone. Conclusion The need for right balanced diet, regular exercise and a stress free life is essential for prevention and management of diabetes and hypertension. 


Download data is not yet available.


Metrics Loading ...

Article Details



Farooqui, Akhlaq A., and Tahira Farooqui. "Contribution of Diabetes and Metabolic Syndrome in the Pathogenesis of Alzheimer’s Disease." Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. 2018. 301-316.

American Diabetes Association. "2. Classification and diagnosis of diabetes: standards of medical care in diabetes—2018." Diabetes Care 41.Supplement 1 (2018): S13-S27.

Rohmetra A, Tandon R, Jaiswal A, Rai R, Srivastava RK. Orthodontic plight: Diabetes mellitus. International Journal of Oral Health Sciences. 2018 Jan 1;8(1):13.

American Diabetes Association. Diabetes Care; 21 January 1998 (Suppl. 1): S23-S31,

Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998; 339:229-234.

Gotto AM Jr. Cardiologist’s role in improving glucose control and global cardiovascular risk in patients with type 2 diabetes mellitus. Am J Cardiol. 2007 99:3–5.

Miljanovic B, Glynn RJ, Nathan DM, Manson JE, Schaumberg DA. A prospective study of serum lipids and risk of diabetic macular edema in type 1 diabetes. Diabetes.2004; 53:2883–2892.

Bertoli A, Di Daniele N, Ceccobelli M, Ficara A, Girasoli C, De Lorenzo A. Lipid profile, BMI, body fat distribution, and aerobic fitness in men with metabolic syndrome. Acta Diabetol. 2003; 40: 30-133,

Hu D, Hannah J, Gray RS, Jablonski KA, Henderson JA, Robbins DC, et al. Effects of obesity and body fat distribution on lipids and lipoproteins in nondiabetic American Indians: The Strong Heart Study. Obes Res.2000; 8: 411-421.

Devrajani, B.R., S.Z. Shah, A.A. Soomro and T. Devrajani, Type 2 diabetes mellitus: A risk factor for Helicobacter pylori infection: A hospital based case-control study. Int J Diabetes Dev Ctries, 2010; 30 (1): 22-6.

Sachidananda G1, Manjunath M.L, Naveen S. Kotur. Blood pressure, lipid profile and lipid peroxidation in Diabetic hypertensive patients. IJBAR; 2012;03(04) 244-247.

Keen, H. Glucose intolerance in diabetes mellitus and atherosclerosis – Prospects for prevention. Post Grad Med J. 1976; 9: 52: 445.

Suryawanshi K. S, Jagtap. P. E., Belwalkar. G. J., Dhonde. S. P., Mane.V.P, More. S. J., To study serum uric acid, serum lipid profile in type-2 diabetes mellitus, SSRG International Journal of Medical Science (SSRG-IJMS) Issue 5 May 2015 – volume 2

Lorenzo Gordon, Dalip Ragoobirsingh, Errol Y St A Morrison, Eric Choo-Kang, Donovan McGrowder, E Martorell. Lipid Profile of Type 2 Diabetic and Hypertensive Patients in the Jamaican Population. Journal of Laboratory Physicians Jan-Jun 2010 Vol-2 / Issue-1/25-30/.

Raksha Goyal & Nandini Sarwate. A correlative study of hypertension with lipid profile. IMPACT: IJRANSS ISSN (E): 2321-8851; ISSN (P): 2347-4580 Feb 2014 Vol. 2, Issue 2, 143-150.

Asatoor, A. M., and King, E. J. Estimation of Blood Glucose levels (1954). Biochem. J., 56, 44P.

Sackett, 0. E.,Estimation of Serum Cholesterol. J Bwl Chein (1925) 64, 203.

Caraway WT. Determination of uric acid in serum by a carbonate method. Am J Clin Pathol. 1955 Jul;25(7):840–845.

An Enzymatic Method for the Determination of Free Fatty Acids in Serum/Plasma Ahmet K?z?ltunç / Fatih Akçay Published Online: 2005-06 01|


Paththinige C, Sirisena N, Dissanayake V. Genetic determinants of inherited susceptibility to hypercholesterolemia – a comprehensive literature review. Lipids in Health and Disease. 2017;16:103. doi:10.1186/s12944-017-0488-4.

Togha M, Gheini MR, Ahmadi B, Khashaiar P, Razeghi S. Lipid profile in cerebrovascular accidents. Iranian Journal of Neurology. 2011;10(1-2):1-4.

DeFronzo RA. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia. 2010;53(7):1270-1287. doi:10.1007/s00125-010-1684-1.

Kones R. Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes. Vascular Health and Risk Management. 2013;9:617-670. doi:10.2147/VHRM.S37119.

Nwanjo HU. Efficacy of aqueous extract of Vernonia amydalina in plasma lipoprotein and oxidative status in diabetic rats. Nig JPhysiol Sci. 2005; 20(1-2): 39-42.

Tenenbaum A, Klempfner R, Fisman EZ. Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor. Cardiovascular Diabetology. 2014;13:159. doi:10.1186/s12933-014-0159-y.

Hall JE. Pathophysiology of obesity hypertension. Current hypertension reports. 2000;2 (2):139-47.

Sri Sri Paramhansa Yogananda. Scientific Healing Affirmations, 2015 Pg-47.