Synthesis and Study of Influence of the Methylene Group Quantity on the Structural Behavior of Polymethylene-Quinazolinethiones.
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Abstract
6,7,8,10-Tetrahydropyrrolo[2,1-b]quinazolin-10-thione (4), 6,7,8,9-tetrahydro-11H-pyrido[2,1-b] quinazoline-11-thione (5), and their seven-membered homologue - 6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-12-thione (6) have been synthesized by interaction of corresponding quinazolones (1-3) with phosphorus pentasulfide. First time the comparable X-ray crystal structure analysis of polymethylenequinazolinethiones (4-6) are studied. It was revealed some regularity of the structure of obtained thiones 4-6 by XRD and identified the conformational state cycloalkanoic rings and the reactivity of the methylene protons at C-6.
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Nasrullaev, A., Turgunov, K., Zhurayev, B., Kadyrov, A., & Elmuradov, B. (2022). Synthesis and Study of Influence of the Methylene Group Quantity on the Structural Behavior of Polymethylene-Quinazolinethiones. Journal of Basic and Applied Research in Biomedicine, 2(4), 552–555. Retrieved from https://www.jbarbiomed.com/index.php/home/article/view/131
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