Formulation and Evaluation of Chitosan-Gellan Beads as Controlled Drug Delivery System of Antihypertensive Drug

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Rohit Bhosale
Riyaz Ali Osmani
H. Gangadharappa
D. Gowda
Afrasim Moin


The use of natural polymers in the design of drug delivery formulation has received much attention due to their excellent biocompatibility and biodegradability. Among them, chitosan and gellan are very promising and have been widely exploited in pharmaceutical industry for controlled drug release. In the present study, an attempt has been made to formulate chitosan-gellan beads of Diltiazem hydrochloride using chitosan and gellan as ionic polysaccharide, and calcium chloride as cross-linking agent. The formulations were prepared by varying the concentration of gellan gum and chitosan. The prepared beads were evaluated for drug polymer interaction by FT-IR, DSC andsurface morphology by SEM. Drug content, swelling studies and in vitro drug release were carried out on prepared beads. FT-IR and DSC studies showed no interaction between drug and polymers. SEM showed spherical nature of beads with inward dents. Swelling of beads depends upon pH, concentration of polymers and crosslinking agent. The in vitro release of drug from beads was controlled for 12 h. Chitosan-gellan beads as controlled drug delivery were prepared by changing the polymer concentration. Swelling studies showed that with an increase in pH from acidic to basic, a considerable increase in swelling in all the formulations was observed


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Journal of Basic And Applied Research


Agnihotri, S. A., Jawalkar, S. S., Aminabhavi, T. M. (2006). Controlled release of cephalexin through gellan gum beads: Effect of formulation parameters on entrapment efficiency, size, and drug release. Eur J Pharm Biopharm, 63, 249-61.

Akbuga, J., Sezer, A. D. (1995). Controlled release of piroxicam from chitosan beads. Int J Pharm, 121, 113-6.

Aminabhavi, T. M., Agnihotri, S. A., Mallikarjuna, N. (2004). Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release, 100, 5-28.

Anal, A. K., Stevens, W. F. (2005). Chitosan-alginate multilayer beads for controlled release of ampicillin. Int J Pharm, 290, 45-54.

Bajpai, S. K., Tankhiwale, R. (2006). Investigation of water uptake behavior and stability of calcium alginate/chitosan bi-polymeric beads: Part 1. Reactive Funct Polymers, 66, 645-58.

Chien, Y. W. (2nd Eds.). (1992). Parentral drug delivery and delivery systems. New York: Marcel dekker.

Fishburn, A. G. (1965). An introduction to pharmaceutical formulation. New York: Pergamon Press.

Fujji, T., Ogiwara, D., Ohkawa, K., Yamamoto, H. (2005). Alkaline phosphatase encapsulated in gellan-chitosan hybrid capsules. Macromol Biosci, 5, 394-400.

Hejazi, R., Amiji, M. (2003). Chitosan-based gastrointestinal delivery systems. J Control Release, 89, 151-165.

Kedzierewicz, F., Lombry, C., Rios, R., Hoffmann, M., Maincent, P. (1999). Effect of the formulation on the in vitro release of propanolol from gellan beads. Int J Pharm, 178(1), 129-36.

Liu, M., Chen, S., Jin, S., Wang, B. (2008). Preparation of ionic-crosslinked chitosan-based gel beads and effect of reaction conditions on drug release behaviors. Int J Pharm, 349, 180-7.

Neau, S. H., Alsarra, I. A., Betigeri, S. S., Zhang, H., Evans, B. A. (2002). Molecular weight and degree of deacetylation effects on lipase-loaded chitosan bead characteristics. Biomaterials, 23, 3637-44.

Pasparakis, G., Bouropoulos, N. (2006). Swelling studies and in vitro release of verapamil from calcium alginate-chitosan beads. Int J Pharm, 323, 34-42.

Patil, S., Sharma, S., Nimbalkar, A., Pawar, A. (2006). Study of formulation variables on properties of drug-gellan beads by factorial design. Drug Dev Ind Pharm, 32, 315-326.

Torrado, S., Prada, P., Torre, P. M., Torrado, S. (2004). Chitosan-poly (acrylic) acid polyionic complex: in vivo study to demonstrate prolonged gastric retention. Biomaterials, 25, 917-23.